研究発表

2023

Emiko Urano, Yumi Itoh, Tatsuya Suzuki, Takanori Sasaki, Jun-Ichi Kishikawa, Kanako Akamatsu, Yusuke Higuchi, Yusuke Sakai, Tomotaka Okamura, Shuya Mitoma, Fuminori Sugihara, Akira Takada, Mari Kimura, Shuto Nakao, Mika Hirose, Tadahiro Sasaki, Ritsuko Koketsu, Shunya Tsuji, Shota Yanagida, Tatsuo Shioda, Eiji Hara, Satoaki Matoba, Yoshiharu Matsuura, Yasunari Kanda, Hisashi Arase, Masato Okada, Junichi Takagi, Takayuki Kato, Atsushi Hoshino, Yasuhiro Yasutomi, Akatsuki Saito, Toru Okamoto. An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models. Sci Transl Med.

2022

Urano E, Ueda K, Higuchi M, Furukawa M, Okamura T, Tanaka Y, Yasutomi Y. Establishment of a cynomolgus macaque model of HTLV-1 infection by direct inoculation of ATL patient-derived cell lines for HTLV-1 infection. J Virol.

Shimozawa N, Iwata T, Yasutomi Y. A controlled ovarian stimulation procedure suitable for cynomolgus macaques. Exp Anim.

Nagatake T, Kishino S, Urano E, Murakami H, Kitamura N, Konishi K, Ohno H, Tiwari P, Morimoto S, Node E, Adachi J, Abe Y, Isoyama J, Sawane K, Honda T, Inoue A, Uwamizu A, Matsuzaka T, Miyamoto Y, Hirata SI, Saika A, Shibata Y, Hosomi K, Matsunaga A, Shimano H, Arita M, Aoki J, Oka M, Matsutani A, Tomonaga T, Kabashima K, Miyachi M, Yasutomi Y, Ogawa J, Kunisawa J. Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques. Mucosal Immunol.

2021

Yamaguchi T, Hoshizaki M, Minato T, Nirasawa S, Asaka MN, Niiyama M, Imai M, Uda A, Chan JF, Takahashi S, An J, Saku A, Nukiwa R, Utsumi D, Kiso M, Yasuhara A, Poon VK, Chan CC, Fujino Y, Motoyama S, Nagata S, Penninger JM, Kamada H, Yuen KY, Kamitani W, Maeda K, Kawaoka Y, Yasutomi Y, Imai Y, Kuba K.  ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury.  Nat Commun.

Urano E, Okamura T, Ono C, Ueno S, Nagata S, Kamada H, Higuchi M, Furukawa M, Kamitani W, Matsuura Y, Kawaoka Y, Yasutomi Y.  COVID-19 cynomolgus macaque model reflecting human COVID-19 pathological conditions.  Proc Natl Acad Sci U S A.

Okamura T, Shimizu Y, Asaka MN, Kanuma T, Tsujimura Y, Yamamoto T, Matsuo K, Yasutomi Y.  Long-term protective immunity induced by an adjuvant-containing live-attenuated AIDS virus.  NPJ Vaccines.

Asaka MN, Utsumi D, Kamada H, Nagata S, Nakachi Y, Yamaguchi T, Kawaoka Y, Kuba K, Yasutomi Y.  Highly susceptible SARS-CoV-2 model in CAG promoter-driven hACE2-transgenic mice.  JCI Insight.

Koinuma S, Shimozawa N, Yasutomi Y, Kimura N.  Aging induces abnormal accumulation of Aβ in extracellular vesicle and/or intraluminal membrane vesicle-rich fractions in nonhuman primate brain.  Neurobiol Aging.

Nakahashi-Ouchida R, Uchida Y, Yuki Y, Katakai Y, Yamanoue T, Ogawa H, Munesue Y, Nakano N, Hanari K, Miyazaki T, Saito Y, Umemoto S, Sawada SI, Mukerji R, Briles DE, Yasutomi Y, Akiyoshi K, Kiyono H.  A nanogel-based trivalent PspA nasal vaccine protects macaques from intratracheal challenge with pneumococci.  Vaccine.

Honda T, Gomi S, Yamane D, Yasui F, Yamamoto T, Munakata T, Itoh Y, Ogasawara K, Sanada T, Yamaji K, Yasutomi Y, Tsukiyama-Kohara K, Kohara M.  Development and Characterization of a Highly Sensitive NanoLuciferase-Based Immunoprecipitation System for the Detection of Anti-Influenza Virus HA Antibodies.  mSphere.

Pai C, Nakayama S, Ito-Fujishiro Y, Kanayama K, Munesue Y, Sankai T, Yasutomi Y, Koie H, Ageyama N.  Usefulness of cardiac hormones for evaluating valvular disease in cynomolgus monkeys (Macaca fascicularis).  J Vet Med Sci.

Shimozawa N, Ageyama N, Nakayama S, Koie H, Yasutomi Y.  Ultrasound-guided, Transabdominal, Intrauterine Artificial Insemination for Cynomolgus Macaques (Macaca fascicularis) Based on Estimated Timing of Ovulation.  J Am Assoc Lab Anim Sci.

Tajiri K, Imanaka-Yoshida K, Tsujimura Y, Matsuo K, Hiroe M, Aonuma K, Ieda M, Yasutomi Y.  A New Mouse Model of Chronic Myocarditis Induced by Recombinant Bacille Calmette-Guèrin Expressing a T-Cell Epitope of Cardiac Myosin Heavy Chain-α.  Int J Mol Sci.

2020

Tsujimura Y, Shiogama Y, Soma S, Okamura T, Takano J, Urano E, Murakata Y, Kawano A, Yamakawa N, Asaka MN, Matsuo K, Yasutomi Y. Vaccination with intradermal bacillus Calmette-Guerin (BCG) provides robust protection against extrapulmonary tuberculosis but not pulmonary infection in cynomolgus macaques.J. Immunol in press

Kato S, Shida H, Okamura T, Zhang X, Miura T, Mukai T, Inoue M, Shu T, Naruse TK, Kimura A, Yasutomi Y, Matsuo K. CD8 T Cells Show Protection against Highly Pathogenic Simian Immunodeficiency Virus (SIV) after Vaccination with SIV Gene-Expressing BCG Prime and Vaccinia Virus/Sendai Virus Vector Boosts. J Virol. 2020 Oct 21:JVI.01718-20.

Nakayama S, Koie H, Pai C, Ito-Fujishiro Y, Kanayama K, Sankai T, Yasutomi Y, Ageyama N. Echocardiographic evaluation of cardiac function in cynomolgus monkeys over a wide age range.  Exp Anim. 2020 Mar 13. doi: 10.1538/expanim.19-0128. [Epub ahead of print]

Kawai S, Annoura T, Araki T, Shiogama Y, Soma S, Takano JI, Sato MO, Kaneko O, Yasutomi Y, Chigusa Y  Development of an effective alternative model for in vivo hypnozoite-induced relapse infection: A Japanese macaque (Macaca fuscata) model experimentally infected with Plasmodium cynomolgi.. Parasitol Int. 2020 Feb27;76:102096. doi: 10.1016/j.parint.2020.102096. [Epub ahead of print]

Fujimoto M, Matsumoto T, Serada S, Tsujimura Y, Hashimoto S, Yasutomi Y, Naka T. Leucine-rich alpha 2 glycoprotein is a new marker for active disease of tuberculosis Sci Rep. 2020 Feb 25;10(1):3384. doi: 10.1038/s41598-020-60450-3.

Araki T, Kawai S, Kakuta S, Kobayashi H, Umeki Y, Saito-Nakano Y, Sasaki T, Nagamune K, Yasutomi Y, Nozaki T, Franke-Fayard B, Khan SM, Hisaeda H, Annoura T. Three-dimensional electron microscopy analysis reveals endopolygeny-like nuclear architecture segregation in Plasmodium oocyst development. Parasitol Int. 2020 Jun;76:102034. doi: 10.1016/j.parint.2019.102034.

2019

Sanada T, Yamamoto N, Kayesh MEH, Tsukiyama-Kohara K, Hasegawa H, Miyazaki T, Takano JI, Shiogama Y, Yasutomi Y, Goh Y, Yoshida O, Hiasa Y, Kohara M。 Intranasal vaccination with HBs and HBc protein combined with carboxyl vinyl polymer induces strong neutralizing antibody, anti-HBs IgA, and IFNG response. Biochem Biophys Res Commun. 2019 Nov 26;520(1):86-92.

Araki T, Kawai S, Kakuta S, Kobayashi H, Umeki Y, Saito-Nakano Y, Sasaki T, Nagamune K, Yasutomi Y, Nozaki T, Franke-Fayard B, Khan SM, Hisaeda H, Annoura T. Three-dimensional electron microscopy analysis reveals endopolygeny-like nuclear architecture segregation in Plasmodium oocyst development. Parasitol Int. 2019Dec2:102034.doi10.1016/j.parint.2019.102034.:

Sanada T, Tsukiyama-Kohara K, Shin-I T, Yamamoto N, Kayesh MEH, Yamane D, Takano JI, Shiogama Y, Yasutomi Y, Ikeo K, Gojobori T, Mizokami M, Kohara M.  Construction of complete Tupaia belangeri transcriptome database by whole-genome and comprehensive RNA sequencing.
Sci Rep. 2019 Aug 26;9(1):12372.

Nakayama S, Koie H, Kato-Tateishi M, Pai C, Ito-Fujishiro Y, Kanayama K, Sankai T, Yasutomi Y, Ageyama N. Establishment of a new formula for QT interval correction using a large colony of cynomolgus monkeys. Exp Anim. 2019 Jul 12. doi: 10.1538/expanim.19-0009.

Mizuno S, Soma S, Inada H, Kanuma T, Matsuo K, Yasutomi Y. SOCS1 antagonist-expressing recombinant BCG enhances anti-tuberculosis protection in a mouse model J.Immunol 203;188-197, 2019.

i Bu W, Joyce MG, Nguyen H, Banh DV, Aguilar F, Tariq Z, Yap ML, Tsujimura Y, Gillespie RA, Tsybovsky Y, Andrews SF, Narpala SR, McDermott AB, Rossmann MG, Yasutomi Y, Nabel GJ, Kanekiyo M, Cohen JI,  Immunization with components of the viral fusion apparatus elicits antibodies that neutralize Epstein-Barr virus in B cells and epithelial cells. Immunity 50:1305-1316,2019.

Sanada T, Yasui F, Honda T, Kayesh MEH, Takano JI, Shiogama Y, Yasutomi Y, Tsukiyama-Kohara K, Kohara M. Avian H5N1 influenza virus infection causes severe pneumonia in the Northern tree shrew (Tupaia belangeri).Virology. 529:101-110,2019.

Yamamoto T, Masuta Y, Momota M, Kanekiyo M, Kanuma T, Takahama S, Moriishi E, Yasutomi Y, Saito T, Graham BS, Takahashi Y, Ishii KJ.A unique nanoparticulate TLR9 agonist enables a HA split vaccine to confer FcγR-mediated protection against heterologous lethal influenza virus infection.Int Immunol. 31:81-90,2019.

Takeuchi S, Ueda N, Suzuki K, Shimozawa N, Yasutomi Y, Kimura N. Elevated Membrane Cholesterol Disrupts Lysosomal Degradation to Induce β-Amyloid Accumulation: The Potential Mechanism Underlying Augmentation of β-Amyloid Pathology by Type 2 Diabetes Mellitus.
Am J Pathol. 1892:391-404, 2019.

Yamamoto T., Kanuma T, Takahama S, Okamura T, Moriishi E, Ishii KJ, Terahara, K, Yasutomi Y. STING agonists activate latently infected cells and enhance SIV-specific responses ex vivo in naturally SIV controlled cynomolgus macaques Sci Rep 9(1):5917, 2019.

Ageyama,N.,Kurosawa,H., Fujimoto,O., Uehara,T., Hiroe,M., Arano,Y., Yoshida,T., Yasutomi,Y., Imanaka-Yoshida,K. Successful Inflammation Imaging of Non-Human Primate Hearts Using an Antibody Specific for Tenascin-C. Int Heart J 60:151-158,2019.

Nakatake M., Kurosaki H., Kuwano N., Horita K., Ito M., Kono H., Okamura T., Hasegawa K., Yasutomi Y., Nakamura T. Partial Deletion of Glycoprotein B5R Enhances Vaccinia Virus Neutralization Escape while Preserving Oncolytic Function. Mol Ther Oncolytics 14:159-171, 2019 

2018

Mutai, H., Miya, H., Shibata,H., Yasutomi,Y., Tsunoda,T., Matsunaga,T Gene 1 expression dataset for whole cochlea of Macaca fascicularis .Sci Rep. 8:15554,2018


Soma S, Kawai S, Inada H, Watanabe K, Mizuno S, Kato S, Matsuo K, Yasutomi Y, Primary role of suppressor of cytokine signaling 1 in Mycobacterium bovis BCG infection. Infection and Immunity 30:471-480,2018.

Nagatake T, Suzuki H, Hirata SI, Matsumoto N, Wada Y, Morimoto S, Nasu A, Shimojou M, Kawano M, Ogami K, Tsujimura Y, Kuroda E, Iijima N, Hosomi K, Ishii KJ, Nosaka T, Yasutomi Y, Kunisawa J. Immunological association of inducible bronchus-associated lymphoid tissue organogenesis in Ag85B-rHPIV2 vaccine-induced anti-tuberculosis mucosal immune responses in mice. Int Immunol 30(10):471-481, 2018.

Kobayashi M., Koyama T., Yasutomi Y., Sankai T. Relationship between menarche and fertility in long-tailed macaques (Macaca fascicularis). J Reprod Dev 67: 601-604, 2018.

Tougan T, Arisue N, Itagaki S, Katakai Y, Yasutomi Y, Horii T. Adaptation of the Plasmodium falciparum FCB strain for in vitro and in vivo analysis in squirrel monkeys (Saimiri sciureus).Parasitol Int 67(5):601-604, 2018

Fujishiro YI, Koie H, Nakayama S, Shibata H, Okabayashi S, Katakai Y, Kanayama K, Yasutomi Y, Ageyama N. Superparamagnetic Iron Oxide-enhanced Magnetic Resonance Imaging of Spontaneous Hepatic Neoplasia in a Cynomolgus Macaque (Macaca fascicularis). Comp. Med. 68:233-238, 2018.

Masuta Y, Yamamoto T, Natsume-Kitatani Y, Kanuma T, Moriishi E, Kobiyama K, Mizuguchi K, Yasutomi Y, Ishii KJ. An Antigen-Free, Plasmacytoid Dendritic Cell-Targeting Immunotherapy To Bolster Memory CD8+ T Cells in Nonhuman Primates. J Immunol.; 200,:2067-2075,2018

Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata SI, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J. The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques. J Allergy Clin Immunol. 142;470-484,2018.

Ikeda Y, Nishiguch KMi, Miya F, Shimozawa N, Funatsu J, Nakatake S, Fujiwara K, Tachibana T, Murakami Y, Hisatomi T, Yoshida S, Yasutomi Y, Ishibashi T and Sonoda K. Retinitis pigmentosa in the cynomolgus monkey (Macaca fascicularis) Investigative Ophthalmology and Visual Science 59:826-830, 2018

Tsujimura Y, Yasutomi Y. Development of a mucosal TB vaccine using human parainfluenza type 2 virus (HPIV2). Mucosal Vaccine Book (Innovation for Preventing Infectious Diseases, 2e, Chapter 38, 2018

Yamamoto T., Kanuma T, Takahama S, Okamura T, Moriishi E, Ishii KJ, Terahara, K, Yasutomi Y. STING agonists activate latently infected cells and enhance SIV-specific responses ex vivo in naturally SIV controlled cynomolgus macaques Sci Rep. 9:5917-5920,2018

2017

Ikeda Y, Nishiguch KMi, Miya F, Shimozawa N, Funatsu J, Nakatake S, Fujiwara K, Tachibana T, Murakami Y, Hisatomi T, Yoshida S, Yasutomi Y, Ishibashi T and Sonoda K. Retinitis pigmentosa in the cynomolgus monkey (Macaca fascicularis) Investigative Ophthalmology and Visual Science in press

Tsujimura Y, Yasutomi Y. Development of a mucosal TB vaccine using human parainfluenza type 2 virus (HPIV2). Mucosal Vaccine. in press.

Masuta Y, Yamamoto T, Natsume-Kitatani Y, Kanuma T, Moriishi E,  Kobiyama K, Mizuguchi K, Yasutomi Y,| Ishii KJ. An antigen-free, pDC-targeting immunotherapy to bolster memory CD8+ T cells in non-human primates. J.Immunol in press

Kayesh MEH, Ezzikouri S, Chi H, Sanada T, Yamamoto N, Kitab B, Haraguchi T, Matsuyama R, Nkogue CN, Hatai H, Miyoshi N, Murakami S, Tanaka Y, Takano JI, Shiogama Y, Yasutomi Y, Kohara M, Tsukiyama-Kohara K. Interferon-β response in impaired by hepatitis B virus infection in Tupaia belangeri. Virus Res 237:47-57, 2017.

Nakayama S, Koie H, Kanayama K, Katakai Y, Ito-Fujishiro Y, Sankai T, Yasutomi Y, Ageyama N. Establishment of reference values for complete blood count and blood gases in cynomolgus monkeys (Macaca fascicularis). J Vet Med 79:881-888, 2017

2016

Okamura T., Tsujimura Y., Soma S., Takahashi I., Matsuo K., Yasutomi Y. Simian immunodeficiency virus SIVmac239 infection and simian human immunodeficiency virus SHIV89.6P infection result in progression to AIDS in cynomolgus macaques from Asian country origin. J General Virol in press

Uchihara T., Endo K., Kondo H., Okabayashi S., Shimozawa N., Yasutomi Y., Adachi E., Kimura N. Tau pathology in aged cynomolgus monkeys is progressive suranuclear palsy/corticobasal degeneration – but not Alzheimer disese -like-ultrastructural mapping of tau by EDX-. Acta Neiropathologica Commun. 2016 in press

Kobayashi M., Koyama T., Yasutomi Y., Sankai T. Male mate choice among captive long-tailed macaques (Macaca fascicularis) Int J Comp Physiol in press

Kimura N, Samura E, Suzuki K, Okabayashi S, Shimozawa N, Yasutomi Y. Dynein Dysfunction Reproduces Age-Dependent Retromer Deficiency: Concomitant Disruption of Retrograde Trafficking Is Required for Alteration in β-Amyloid Precursor Protein Metabolism. Am J Pathol 186:1952-1966, 2016.

Tajiri K., Yasutomi Y., Aonuma K.  Recent advances in the management of autoimmune myocarditis: insights from animal studies. Curr Pharm Des. 22;427-439,2016.

Suzuki S., Mori KI., Higashino A., Iwasaki Y., Yasutomi Y, Maki N., Akari H. Persistent replication of a hepatitis C virus genotype 1b-based chimeric clone carrying E1, E2 and p6 regions from GB virus in a Neew World monkey. Midrobiol Immunol. 60;26-34, 2016.

Tsujimura Y., Yasutomi Y. Allergy vaccines using Mycobacterium secreted antigen and IL-4 antagonist. Methods Mol. Biol. 1403:723-738,2016.

Fujishiro Y., KoieH., Shibata H., Okabayashi S., Katakai Y., Ohno C., Kanayama K., Yasutomi Y., Ageyama N. Tracking cells implanted into cynomolgus monkeys (Macaca fascicularis) using MRI. Exp Anim. 2016 Jul 29;65(3):311-8.

2015

Tajiri K., Yasutomi Y., Aonuma K.  Recent advances in the management of autoimmune myocarditis: insights from animal studies. Curr Pharm Des. 2015 E-pub

Suzuki S., Mori KI., Higashino A., Iwasaki Y., Yasutomi Y, Maki N., Akari H. Persistent replication of a hepatitis C virus genotype 1b-based chimeric clone carrying E1, E2 and p6 regions from GB virus in a Neew World monkey. Midrobiol Immunol. 2015 E-pub

Aoshi T, Haseda Y, Kobiyama K, Narita H, Sato H, Nankai H, Mochizuki S, Sakurai K, Katakai Y, Yasutomi Y, Kuroda E, Coban C, Ishii KJ. Development of non-aggregating poly-A tailed immunostimulatory A/D-type CpG oligodeoxynucleotides applicable for clinical use. J.Immunopl.Res. 2015; E-pub

Fukuyama Y., Yuki Y., Katakai Y., Harada N., Takahashi H., Takeda S., Mjima M., Joo S., Kurokawa S., Sawada S., Shibata H., Park EJ., Fujihashi K., Briles DE., Yasutomi Y., Tsukada H., Akiyoshi K. and Kiyono H. Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumonia in macaques. Mucosal Immunology 2015:8;1144-1153.

Okabayashi S, Shimozawa N, Yasutomi Y, Yanagisawa K, Kimura N. Diabetes mellitus accelerates A pathology in brain accompanied by enhanced GAβ generation in nonhuman primates PLos One 2015 E-pub,

Onishi M, Ozasa K, Kobiyama K, Ohata K, Kitano M, Taniguchi K, Homma T, Kobayashi M, Sato A, Katakai Y, Yasutomi Y, Wijaya E|, Igarashi Y, Nakatsu N, Ise W, Inoue T, Yamada H, Vandenbon A|, Standley DM|, Kurosaki T, Coban C, Aoshi T, Kuroda E, Ishii KJ. Hydroxypropyl-β-cyclodextrin spikes local inflammation that induce Th2 and Tfh responses to the coadministered antigen. J. Immunol. 2015:194;2673-2682

Tachibana SI, Kawai S, Katakai Y, Takahashi H, Nakade T, Yasutomi Y, Horii T, Tanabe K. Contrasting infection susceptibility of the Japanese macaques and cynomolgus macaques to closely related malaria parasites, Plasmodium vivax and Plasmodium cynomolgi. Parasitol. Int. 2015:64;274-281.

2014

Okabayashi S, Shimozawa N, Yasutomi Y, Yanagisawa K, Kimura N. Diabetes mellitus accelerates Ab pathology in brain accompanied by enhanced GAβ generation in nonhuman primates PLos One in press

Onishi M, Ozasa K, Kobiyama K, Ohata K, Kitano M, Taniguchi K, Homma T, Kobayashi M, Sato A, Katakai Y, Yasutomi Y, Wijaya E|, Igarashi Y, Nakatsu N, Ise W, Inoue T, Yamada H, Vandenbon A|, Standley DM|, Kurosaki T, Coban C, Aoshi T, Kuroda E, Ishii KJ. Hydroxypropyl-b-cyclodextrin spikes local inflammation that induce Th2 and Tfh responses to the coadministered antigen J. Immunol. in press

Watanabe K., Matsubara A, Kawano M, Mizuno S, Okamura T, Tsujimura Y, Inada H, Nosaka T, Matsuo K. and Yasutomi Y. Recombinant Ag85B vaccine by taking advantage of characteristics of human parainfluenza type 2 virus vector showed Mycobacteria-specific immune responses by intranasal immunization. Vaccine 2014:32;1727-1735.

Kobiyama K., Aoshi T., Narita H., Kuroda E., Hayashi M., Tetsutani K., Koyama S., Mochizuki S., Sakurai K., Katakai Y., Yasutomi Y., Saijo S., Iwakura Y., Akira S., Coban C. and Ishii KJ. A non-agonistic Dectin-1 ligand transforms CpG into a multitask nano-particulate TLR9 agonist. Proc. Natl. Acad Sci. USA 2014:111;3086-3091.

Tsujimura Y, Inada H, Yoneda M, Fujita T, Matsuo K. and Yasutomi Y.  Effects of Mycobacteria major secretion protein, Ag85B, on allergic inflammation in the lung. PLos One 2014;9: E-pub

Saito N, Chono H, Shibata H, Ageyama N, Yasutomi Y. and Mineo J. CD4(+) T cells modified by the endoribonuclease MazF are safe and can persist in SHIV-infected rhesus macaques. Mol Ther. Nuleic Acids 2014:E-pub

Machino-Ohtsuka T, Tajiri K, Kimura T, Sakai S, Sato A, Yoshida T, Hiroe M, Yasutomi Y, Aonuma K, Imanaka-Yoshida K. Tenascin-C aggravates autoimmune myocarditis via dendritic cell activation and Th17 cell differentiation. J.Am.Heart Assoc. 2014 E-pub

Tachibana SI, Kawai S, Katakai Y, Takahashi H, Nakade T, Yasutomi Y, Horii T, Tanabe K. Contrasting infection susceptibility of the Japanese macaques and cynomolgus macaques to closely related malaria parasites, Plasmodium vivax and Plasmodium cynomolgi. Parasitol. Int. 2014 E-pub

Saito N, Chono H, Shibata H, Ageyama N, Yasutomi Y. and Mineo J. CD4(+)
T cells modified by the endoribonuclease MazF are safe and can persist in
SHIV-infected rhesus macaques. Mol Ther. Nuleic Acids 2014:E-pub

2013

Watanabe K., Matsubara A, Kawano M, Mizuno S, Okamura T, Tsujimura Y, Inada H, Nosaka T, Matsuo K. and Yasutomi Y. Recombinant Ag85B vaccine by taking advantage of characteristics of human parainfluenza type 2 virus vector showed Mycobacteria-specific immune responses by intranasal immunization. Vaccine in press

Wada T, Kohara M, Yasutomi Y.DNA vaccine expressing the non-structural proteins of hepatitis C virus diminishes the expression of HCV proteins in a mouse model.
Vaccine 2013:31;5968-5974.

Kitagawa H, Kawano M, Yamanaka K, Kakeda M, Tsuda K, Inada H, Yoneda M, Sakaguchi T, Nigi A, Nishimura K, Komada H, Tsurudome M, Yasutomi Y, Nosaka T, Mizutani H. Intranasally administered antigen 85B gene vaccine in non-replicating human Parainfluenza type 2 virus vector ameliorates mouse atopic dermatitis.
PLoS One. 2013 8(7): e66614
 
Shimozawa N, Ono R, Shimada M, Shibata H, Takahashi I, Inada H, Takada T, Nosaka T, Yasutomi Y.Cynomolgus monkey induced pluripotent stem cells established by using exogenous genes derived from the same monkey species.
Differentiation. 2013 85:131-139.

Tajiri K, Shimojo N, Sakai S, Machino-Ohtsuka T, Imanaka-Yoshida K, Hiroe M, Tsujimura Y, Kimura T, Sato A, Yasutomi Y, Aonuma K.Pitavastatin regulates helper T-cell differentiation and ameliorates autoimmune myocarditis in mice.
Cardiovasc Drugs Ther. 2013, 27:413-424.

Saito A, Nomaguchi M, Kono K, Iwatani Y, Yokoyama M, Yasutomi Y, Sato H, Shioda T, Sugiura W, Matano T, Adachi A, Nakayama EE, Akari H.TRIM5 genotypes in cynomolgus monkeys primarily influence inter-individual diversity in susceptibility to monkey-tropic human immunodeficiency virus type 1.
J Gen Virol. 2013 Jun;94(Pt 6):1318-24.

Yoshida T, Omatsu T, Saito A, Katakai Y, Iwasaki Y, Kurosawa T, Hamano M, Higashino A, Nakamura S, Takasaki T, Yasutomi Y, Kurane I, Akari H.Dynamics of cellular immune responses in the acute phase of dengue virus infection.
Arch Virol. 2013,158:1209-20.

Tougan T, Aoshi T, Coban C, Katakai Y, Kai C, Yasutomi Y, Ishii KJ, Horii T TLR9 adjuvants enhance immunogenicity and protective efficacy of the SE36/AHG malaria vaccine in nonhuman primate models..Hum Vaccin Immunother. 2013 Jan 4;9(2).

Nomaguchi M, Yokoyama M, Kono K, Nakayama EE, Shioda T, Saito A, Akari H, Yasutomi Y, Matano T, Sato H, Adachi A.Gag-CA Q110D mutation elicits TRIM5-independent enhancement of HIV-1mt replication in macaque cells.
Microbes Infect. 2013 J, 5:56-65.

2012

Yoshhida, T., Omatsu, T., Saito, A., Katakai, Y., Iwasaki, Y., Kurosawa, T., Hamano, M., Higashimo, A., Nakamura, S.., Takasaki, T., Yasutomi, Y., Kurane, I. and Akari, H. Dynamics of cellular immune responses in the acute phase of dengue virus infection. Archiv. Virol. in press

Tougan,T., Aoshi,T., Coban,C., Katakai,Y., Kai,C., Yasutomi,Y., Ishii,KJ. and Horii,T. TLR9 adjuvants enhance immunogenicity and protective efficacy of the SE36/AHG malaria vaccine in nonhuman primate models. Hum.Vac.Immunother. 2012 in press

Karamatsu,K., Matsuo,K., Inada,H., Tsujimura,Y., Shiogama,Y., Matsubara,A., Kawano,M. and Yasutomi,Y. Single systemic administration of Ag85B of mycobacteria DNA inhibits allergic airway inflammation in a mouse model of  asthma. J Asthma Allergy 2012;5:71-79.

Nomaguchi,M., Yokoyama,M., Kono,K., Nakayama,E.E., Shioda T., Saito,A., Akari,H., Yasutomi,Y., Matano,T., Sato,H. and Adachi,A. Gag-CA Q110D mutation elicits TRIM5-independent enhancement of HIV-1mt replication in macaque cells. Microve. Infect. in press

Yoshida,T., Omatsu,T., Saito,A., Katakai,Y., Iwasaki,Y., Iijima,S., Kurosawa,T., Hamano,M., Nakamura,S., Takasaki,T., Yasutomi,Y., Kurane.,I Akari,H. CD16 positive natural killer cells play a limited role against primary dengue virus infection in tamarins Archives Virol 2012;15:;363-368.

Tajiri,K., Imanaka-Yoshida,K., Matsubara,A., Tsujimura,Y., Hiroe,M., Naka,T.,Shimojo,N., Sakai,S., Aonuma,K. and Yasutomi,Y. Suppressor of cytokine signaling 1 (SOCS1) DNA administration inhibits inflammatory and pathogenic responses in autoimmune myocarditis. J.Immunol 2012:189;2043-2053.

Uchdida,A., Sasaguri,H., Kimura,N., Tajiri,M., Ohkubo,T., Ono,F., Sakaue,F., Kanai,K., Hirai,T., Sano,T., Shibuya,K., Kobayashi,M., Yamamoto,M., Yokota,S.., Kuboddera,T., Tomori,M., Sakaki,K., Enomoto,M., Hirai,Y., Kumagai,J., Yasutomi,Y., Mochizuki,H., Kuwabara,S., Uchihara,T., Mizusawa,H. and Yokakota,T. Non-human primate model of ALS with cytoplasmic mislocalization of TDP-43. Brain 2012:135;833-846.

Saito,A., Kono,K., Nomaguchi,M., Yasutomi,Y., Adachi,A., Shioda,T., Akari,H. and Nakayama,E. E. Geographical genetic and functional diversity of antiretroviral host factor TRIMCyp in cynomolgus macaque (Macaca fascicularis). J.Gen.Virol. 2012;93:594-602.

Higashino,A., Sakate,R., Kameoka,Y., Takahashi,I., Hirata,M., Tanuma,R., Masui,T., Yasutomi,Y. and Osada,N. Whole-genome sequencing and analysis of the Malaysian cynomolgus macaque (Macaca fascicularis) genome. Genome Biol. 2012 Epub

Tachibana,S., Sullivan,SA., Kawai,S., Nakamura,S., Goto,N., Arisue,N., Palacpac,NMQ., Honma,H., Yagi,M., Tougan,T., Katakai,Y., Kaneko,O., Mita,T., Kita,K., Yasutomi,Y., Kim,HR., Sutton,PL., Shakhbatyan,R., Horii,T., Yasunaga,T., Bamwell,JW., Escalante,AA., Carlton,JM. And Tanabe,K. Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade. Nature Genetics 2012; 44:1051-1055.

2011

Uchdida,A., Sasaguri,H., Kimura,N., Tajiri,M., Ohkubo,T., Ono,F., Sakaue,F.,Kanai,K., Hirai,T., Sano,T., Shibuya,K., Kobayashi,M., Yamamoto,M., Yokota,S.., Kuboddera,T., Tomori,M., Sakaki,K., Enomoto,M., Hirai,Y., Kumagai,J., Yasutomi,Y., Mochizuki,H., Kuwabara,S., Uchihara,T., Mizusawa,H. and Yokakota,T. Non-human primate model of ALS with cytoplasmic mislocalization of TDP-43. Brain in press

Iwasaki,Y., Mori,K., Ishii,K., Maki,N., IIjima,S., Yoshida,T., Okabayashi,S., Katakai,Y., Lee,J., Saito,A., Fukai,H., Kimura,N., Ageyama,N., Yoshizaki,S., Suzuki,T., Yasutomi,Y., Miyamura,T., Kannagi,M. and Akari,H. Longe-term persistent GBV-B infection and development of a chronic and progressive hepatitis C-like diseae in marmosets.
Frontiers Microbiol.  in press

Hirata,H., Kawai,S., Maeda,M., Jinnai,M., Fujisawa,K., Katakai,Y., Hikosaka,K.,Tanabe,K., Yasutomi,Y. and Ishihara,C. Identification and Phylogenetic Analysis of Japanese Macaque Babesia-1 (JM-1) Detected from a Japanese Macaque (Macacafuscata fuscata).
Am.J.Trop.Med.Hyg. in press

Saito,A., Kono,K., Nomaguchi,M., Yasutomi,Y., Adachi,A., Shioda,T., Akari,H. and Nakayama,E.E. Geographic, Genetic, and Functional Diversity of AntiretroviralHost Factor TRIMCyp in Cynomolgus Macaque (Macaca fascicularis)  J.Gen.Virol. in press

Matsuo,K. and Yasutomi,Y. Mycobacterium bovis bacille Calmette-Guérin as a vaccine vector for global infectious disease control.  Tuberculosis Res. Treat. 2011 Epub

Chono,H., Saito,N.. Yasutomi,Y.,Mineno,J., and Kato,I. In vivo safety and persistence of endoribonuclease gene-transduced CD4+ T cells in cynomolgus macaques for HIV-I gene therapy model. PloS One 2011; 6: Epub

Xing, Li., Wang, J.C., Li, T-C., Yasutomi,Y., Lara,J., Purcell,R., Takeda,N., Miyamura,T. and Holland,R.C. Spatial configuration of hepatitis E virus antigenic domain.
J.Virol. 2011;85:1117-1124.

Chono,H., Matsumoto,K., Tsuda,H., Saito,N., Lee,K.., Kim,S., Shibata,H., Ageyama,N., Terao,K., Yasutomi,Y., Mineno J., Kim,S., Inoue,M. and Kato,I. Acquistion of HIV-1 resistance in T lymphocytes using an ACA-specific E.coli mRNA interferase.
Human Gene Ther. 2011;22:35-43.

Okabayashi,S., Uchida,K., Ohno,C., Hanari,K., Goto,I. and Yasutomi,Y. Periventricular Leucomalacia(PVL)-like lesions in two neonatal cynomolgus monkeys (macaca fascicularis).
J.Comp.Pathol. 2011;144:204-211.

Saito,A., Nomaguchi,M., Iijima,S.,Lee,Y-J., Kono,K., Nakayama,E.E., Shioda,T., Yasutomi,Y., Adachi,A., Matano,T., Akari,H. A novel monkey-tropic HIV-1 derivative encoding only minimal SIV sequences can replicate in cynomolgus monkeys.
Micorbes and Infection 2011;13:58-64.

2010

Xing, Li., Wang, J.C., Li, T-C., Yasutomi,Y., Lara,J., Khurdyakaov,Y., Schofield D., Emerson,S., Purcell,R., Takeda,N., Miyamura,T. and Holland,R.C. Spatial configuration of hepatitis E virus antigenic domain. J.Virol. 2010 in press

Naruse,T.K., Zhiyong,C., Yanagida,R., Yamashita,T., Saito,Y., Mori,K., Akari,H., Yasutomi,Y., Matano,T. and Kimura,A. Diversity of MHC class I genes in Burmese-origine rhesus macaques. Immunogenetics 2010 in press.

Chono,H., Matsumoto,K., Tsuda,H., Saito,N., Lee,K.., Kim,S., Shibata,H., Ageyama,N., Terao,K., Yasutomi,Y., Mineno J., Kim,S., Inoue,M. and Kato,I. Acquistion of HIV-1 resistance in T lymphocytes using an ACA-specific E.coli mRNA interferase.
Human Gene Ther. 2010 in press

Okabayashi,S., Uchida,K., Nakayama,H., Ohno,C., Hanari,K., Goto,I. and Yasutomi,Y. Periventricular Leucomalacia(PVL)-like lesions in two neonatal cynomolgus monkeys (macaca fascicularis). J.Comp.Pathol. 2010 in press

Saito,A., Nomaguchi,M., Iijima,S.,Lee,Y-J., Kono,K., Nakayama,E.E., Shioda,T., Yasutomi,Y.,  Adachi,A., Matano,T., Akari,H. A novel monkey-tropic HIV-1 derivative encoding only minimal SIV sequences can replicate in cynomolgus monkeys.
Micorbes and Infection 2010 in press

Yoshida,T., Saito,A., Iwasaki,Y.,Iijima,S., Kurosawa,T., Katakai,Y., Yasutomi,Y., Reimann,K.A., Hayakawa,T. and Akari,H. Characterization of natural killer cells in tamarins: a technical basis for studies of innate immunity.
Frontiers Microbiol. 2010 in press

Yasuhiro Yasutomi. Establishment of Specific Pathogen-Free Macaque Colonies in Tsukuba Primate Research Center of Japan for AIDS research. Vaccine 2010:B75-B77.

Fujimoto,K., Takano,J., Narita,T., Hanari,K., Shimozawa,N., Sankai,T., Yoshida T., Terao,K., Kurata,T. and Yasutomi,Y. Simian Retrovirus type D infection in a colony of cynomolgus monkeys. Comp.Med. 2010;60:51-53.

Cueno,M.E., Karamatsu,K., Yasutomi, Y., Laurena,A.C. and Okamoto.T. Preferential expression and immunogenicity of HIV-1 Tat fusion protein expressed in tomato plant. Transgenic Res. 2010 Epub

2009

Mori,H., Yamanaka,K., Matsuo,K., Yasutomi,Y. and  Mizutani,H.
Administration of Ag85B showed therapeutic effects to Th2-type cytokine-mediated acute phase atopic dermatitis by inducing regulatory T cells.
Arch Dermatol.Res.2009:301;151-157.

Morioka ,K., Yamanaka,K., Yasutomi,Y. and Mizutani, H,
IL-4/IL-13 antagonist DNA vaccination successfully suppresses Th2 type chronic dermatitis.
Br.J.Dermatol. 2009:160;1172-1179.

Okabayashi,S., Ohno,C. and Yasutomi,Y. Acute megakaryocytic leukemia (AMKL)-like disease in a cynomolgus monkey (Macaca fascicularis). J.Comp.Pathol.2009:140:212-216.

Takano,J.I., Tachibana,H., Kato,M., Narita,T., Yanagi,T., Yasutomi,Y. and Fujimoto,K. Entamoeba histolytica-like strains to differentiate them from Entamoeba hystolytica. Parasitol.Res. 2009:105;929-937.

Yasuhiro Yasutomi. Establishment of specific pathigen-free macaque colonies in Tsukuba Primate Research Center of Japan for AIDS research. Vaccine 2009 in press

Fujimoto,K., Takano,J., Narita,T., Hanari,K., Shimozawa,N., Sankai,T., Yoshida,T., Terao,K., Kurata,T and Yasutomi,Y. Simian Retrovirus type D infection in a colony of cynomolgus monkeys. Comp.Med. 2009 in press

2008

Yasuhiro Yasutomi.
Chimeric recombinant hepatitis E virus-like particles presenting foreign epitopes as a novel vector of vaccine by oral administration. 
Holland,CR., an Mitamura,T. Eds.
Structure-based study of viral replication. World Scientific .2008;p539-p552.

Okabayashi,S., Ohno,C., Kato,M., Nakayama H., Yasutomi,Y.
Congenital cystic adenomatoid-like malformation in a cynomolgus monkey (Macaca fascicularis). 
Vet. Path. 2008;45:232-235..

Tsuchida, J., Yoshida,Y., Sankai,T. and Yasutomi,Y.
Maternal behavior of laboratory-born, individually reared long-tailed macaques (Macaca fascicularis).
J.Am.Assoc.Lab.Anim. 2008:47;29-34.

Mori,H., Yamanaka,K., Matsuo,K., Yasutomi,Y. and  Mizutani,H.
Administration of Ag85B showed therapeutic effects to Th2-type cytokine-mediated acute phase atopic dermatitis by inducing regulatory T cells.
Arch Dermatol.Res.2008July Epub ahead

Yasui,F., Kai,C., Kitabatake,M., Inoue, S., Yoneda M., Yokochi,S., Kase,R., Sekiguchi,S., Morita,K., Hishima,T., Suzuki,H., Karamatasu,K., Yasutomi Y., Shida,H., 
idokoro,M., Mizuno,K., Matsushima K. and Kohara,M.
Prior immunization with SARS-CoV nucleocapsid protein causes severe pneumonia in
mice infected with SARS-CoV.
J.Immunol. 2008:47;1-6.

Morioka ,K., Yamanaka,K., Yasutomi,Y. and Mizutani, H,
IL-4/IL-13 antagonist DNA vaccination successfully suppresses Th2 type chronic dermatitis.
Br.J.Dermatol. 2008  in press

松原明弘、唐松克夫、保富康宏.
第III部 ワクチン〜子宮頸癌予防ワクチン〜
新薬展望2008(医薬ジャーナル社) 44(S-1):317-322, 2008

2007

Tanaka-Takahashi,Y., Yasunami,M., Naruse,T., Hinohara,K., Matano T., Mori,K., 
Miyazawa,M., Honda,M., Yasutomi,Y., Nagai,Y. and Kimura,A.
Reference strand-mediated conformation analysis (RSCA)-based typing of multiple allelles in the rhesus macaque MHC class I Mamu-A and Mamu-B loci.
Electrophoresis 2007; 28:918-924.

Nishikubo,K., Imanaka-Yoshida,K., Tamaki,S., Hiroe,M., Yoshida,T., Adachi,Y. and Yasutomi,Y.Th1-type immune responses by Toll-like receptor 4 signaling are required for the development of myocarditis in mice with BCG-induced myocarditis.
J.Autoimmun. 2007;29:146-153.

保富康宏、松原明弘、唐松克夫.
ワクチンの展望5 ウイルス様中空粒子(VLP)を用いた経口ワクチンの開発.
治療学(ライフサイエンス出版) 41(10):1067-1071, 2007